Avantes provides versatile spectroscopy solutions for pharmaceutical applications, including real-time monitoring of drug formulation processes like liposomal encapsulation and dissolution testing. Our fiber optic systems support quality control, process optimization, and regulatory compliance across various stages of pharmaceutical manufacturing.
At Rutgers University’s Center for Structured Organic Particulate Systems (CSOPS), researchers are leveraging Avantes’ dip probe technology for in-line dissolution testing, as well as using near-infrared (NIR) reflection measurements to monitor the active pharmaceutical ingredient (API) content in tablets. Their work highlights how flexible, fiber-optic-based spectroscopy can support real-time, non-destructive pharmaceutical analysis.
Avantes spectrometers have also been used by leading pharmaceutical companies for R&D applications. For example, our HERO spectrometer and ATR probe were previously selected by Pfizer for reaction monitoring efforts in their development labs.
To overcome the complexities of producing liposomal nanoparticles—used in cancer therapies and mRNA vaccines—the FDA and the University of Connecticut developed a continuous manufacturing system with real-time quality control capabilities. A key component of this GMP-compliant platform is the Avantes UV-Vis spectrometer, which was integrated into the process to monitor drug encapsulation in real time.
The spectrometer, used in conjunction with a multivariate predictive algorithm, enabled precise tracking of doxorubicin drug loading during the nanoparticle formation stage. This eliminated the need for offline testing, significantly accelerating development timelines and enhancing process reliability.
Through this setup, the system successfully achieved:
The platform, developed in collaboration with DIANT Pharma, successfully demonstrated a 3-hour controlled run that produced high-quality, doxorubicin-loaded liposomes—meeting regulatory specifications and showcasing the power of inline spectroscopy in modern pharmaceutical production.
My Cart 